Dexamethasone, ‘Major Breakthrough’ drug in covid-19 Fight

A low-dose steroid treatment dexamethasone is now a major breakthrough in the fight against the deadly virus, UK experts say.
According to BBC news, The drug is part of the world’s biggest trial testing existing treatments to see if they would also work for coronavirus.
It cut the risk of death by a third for patients on ventilators. For those on oxygen, it cut deaths by a fifth.
Dexamethasone would had been used to treat patients in the UK from the start of the pandemic, up to 5,000 lives could have been saved, researchers say.
And it could be of huge benefit in poorer countries with high numbers of Covid-19 patients.
Prime Minister Boris Johnson said there was a genuine case to celebrate “a remarkable British scientific achievement”,
Chief Medical Officer for England Prof Chris Whitty said it would save lives around the world.
About 19 out of 20 patients with coronavirus recover without being admitted to hospital.
Of those who are admitted, most also recover but some may need oxygen or mechanical ventilation.
And these are the high-risk patients dexamethasone appears to help.
The drug is already used to reduce inflammation in a range of other conditions, including arthritis, asthma and some skin conditions.
And it appears to help stop some of the damage that can happen when the body’s immune system goes into overdrive as it tries to fight off coronavirus.
In the trial, led by a team from Oxford University, about 2,000 hospital patients were given dexamethasone and compared with more than 4,000 who were not.
For patients on ventilators, it cut the risk of death from 40% to 28%.
For patients needing oxygen, it cut the risk of death from 25% to 20%.
Chief investigator Prof Peter Horby said: “This is the only drug so far that has been shown to reduce mortality – and it reduces it significantly. It’s a major breakthrough.”
Lead researcher Prof Martin Landray said the findings suggested one life could be saved for:
every eight patients on a ventilator
every 20-25 treated with oxygen
“There is a clear, clear benefit,” he said.
“The treatment is up to 10 days of dexamethasone. This is a drug that is globally available.”
When appropriate, hospital patients should now be given it without delay, Prof Landray said.
But people should not go out and buy it to take at home.
Dexamethasone does not appear to help people with milder symptoms of coronavirus who do not need help with their breathing.
The Recovery Trial, running since March, also looked at the malaria drug hydroxychloroquine, which has subsequently been ditched amid concerns it increases fatalities and heart problems.
The antiviral drug remdesivir, meanwhile, which appears to shorten recovery time for people with coronavirus, is already being made available on the NHS .
The first drug proven to cut deaths from Covid-19 is not some new, expensive medicine but an old, cheap-as-chips steroid.
That is something to celebrate because it means patients across the world could benefit immediately.
Dexamethasone has been used since the early 1960s to treat a wide range of conditions, such as rheumatoid arthritis and asthma.
Half of all Covid patients who require a ventilator do not survive, so cutting that risk by a third would have a huge impact.
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Oh Lawd!